Blood Coagulation (Clotting)
It is a well-known fact that the blood thickens during pregnancy, leading to susceptibility to vascular occlusion/ obstruction (embolism). However this condition arises more in some women. Blood coagulation affects the baby’s nourishment, growth and even implantation at first.
Phospholipids are found in the cell membrane, and when the body creates antibodies (a type of secretion) against them, the white cell collection and attack eagerness increase, a susceptibility to vascular occlusion arises.
Phospholipid antibodies are more common in IVF treatments not resulted in pregnancy, recurrent miscarriages, endometriosis, cell tissue damage, and in some cases progressing with cell tissue damage. Lupus Anticoagulant Antibody is one of the antibodies found first. Its presence in the blood does not mean that the woman is a Lupus patient. But it will create problems in embryo implantation. Similarly, Anticardiolipin antibody is also a secretion that increases blood coagulation.
Some gene region mutations also cause susceptibility to coagulation: mutations in Factor V Leiden, F II (Prothrombin), MTHFR 677, MTHFR 1298 region are examples of this. The most common one is Factor V mutation.
It has been shown that aspirin and/or subcutaneous blood thinner injections provided nearly 70% chance to have a baby when susceptibility to blood coagulation is identified.